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Phosphoribosyl Pyrophosphate Amidotransferase (PPAT)
- Target
- PPAT
- Molecular classification
- Enzyme, Purine/pyrimidine phosphoribosyltransferases
01
Overview
Phosphoribosyl pyrophosphate amidotransferase (PPAT) is a key regulatory enzyme that catalyzes the first committed step in de novo purine nucleotide biosynthesis. It converts 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosylamine (PRA), glutamate, and pyrophosphate. Elevated expression or activity is associated with increased cell proliferation and cancer progression, particularly in thyroid cancer. It regulates PKM2 expression and activates ERK/STAT3 pathways involved in tumorigenesis.
- Other names
- AmidophosphoribosyltransferaseATaseGlutamine phosphoribosylpyrophosphate amidotransferaseGPATPUR1 protein
02
Mechanism of action
Inhibition of purine biosynthesis
03
Biological functions
Purine biosynthesisRegulation of nucleotide poolsCell proliferationDNA/RNA synthesisEnergy metabolism
04
Disease associations
Cancer
05
Safety considerations
Potential for disrupting nucleotide balanceSide effects related to inhibiting cell proliferation
06
Biomarkers
PPAT expression levels in cancer tissues
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