Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPSAP1)

Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPSAP1) is a regulatory protein that associates with phosphoribosyl pyrophosphate synthetase (PRPS) enzymes, contributing to the assembly and negative regulation of the PRPS enzymatic complex involved in nucleotide biosynthesis[1][3]. PRPSAP1 does not possess enzymatic activity itself but modulates the activity and architecture of the PRPS complexes—primarily impacting the synthesis of 5-phosphoribose 1-diphosphate, a substrate important for purine and pyrimidine nucleotide biosynthesis[1][3]. It is widely expressed at different levels in various tissues and may play roles in cell viability by influencing PRPS complex formation and flexibility, rather than catalysis[1]. PRPSAP1 is associated with some disease states, particularly through regulatory dysfunction in nucleotide metabolism, and is noted as a gene of interest in cancer research, although it is not considered a direct therapeutic target[3].

Other names

PRPSAP1PAP3939 kDa phosphoribosypyrophosphate synthase-associated proteinPRPP synthase-associated protein 1phosphoribosyl pyrophosphate synthase-associated protein 1