Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPSAP2)

Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPSAP2) is a non-catalytic subunit of the phosphoribosylpyrophosphate synthetase (PRS) complex. The PRS complex is responsible for the synthesis of phosphoribosylpyrophosphate (PRPP), a key metabolic intermediate required for de novo synthesis of nucleotides, certain amino acids (histidine, tryptophan), and NAD. PRPSAP2 does not possess catalytic activity but instead appears to act as a negative regulator of PRPP synthesis. It is encoded by the PRPSAP2 gene and is found in a multi-subunit complex with the PRS catalytic subunits. PRPSAP2 has no documented direct pharmacologic interventions or drugs, nor is it a validated therapeutic target, although it is implicated in the network regulation of cellular nucleotide pools. PRPSAP2 is not an enzyme, receptor, transporter, or a canonical therapeutic target, but rather a non-catalytic, regulatory component of an enzyme complex. It may have relevance in rare genetic diseases when disturbed, but there is no evidence for direct drug targeting. There is no evidence for interacting drugs or clinical biomarkers associated directly with PRPSAP2 as of current knowledge.

Other names

Phosphoribosyl pyrophosphate synthase-associated protein 2PRPP synthase-associated protein 2PAP4141 kDa phosphoribosypyrophosphate synthetase-associated protein