Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Glycinamide Ribonucleotide Transformylase (GARFTase)
- Target
- GARFTase
- Molecular classification
- Enzyme, Formyltransferase
01
Overview
Glycinamide ribonucleotide transformylase (GARFTase) is a key folate-dependent enzyme in the de novo purine biosynthesis pathway. It catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to glycinamide ribonucleotide (GAR), producing formylglycinamide ribonucleotide (FGAR). This reaction is essential for the synthesis of purine nucleotides. As an essential enzyme for cell proliferation, GARFTase is an important target for antitumor drug design. Inhibition disrupts de novo purine synthesis leading to cytotoxicity especially in rapidly dividing cells such as cancer cells.
- Other names
- Phosphoribosylglycinamide formyltransferaseGART
02
Mechanism of action
Inhibition of de novo purine synthesis
03
Biological functions
Purine biosynthesisNucleotide synthesisCell proliferation
04
Disease associations
CancerInflammation
05
Safety considerations
Cytotoxicity due to disruption of nucleotide synthesisPotential for off-target effects on normal cells
06
Interacting drugs
Antifolate drugs
07
Biomarkers
GART expression level in tumor tissue
Beyond the preview
Go deeper on Glycinamide Ribonucleotide Transformylase (GARFTase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Glycinamide Ribonucleotide Transformylase (GARFTase).