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Target intelligence / Profile preview
Phosphoric Diester Hydrolase (PDE)
- Target
- PDE
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Phosphoric diester hydrolases, commonly known as phosphodiesterases (PDEs), are a class of enzymes that catalyze the hydrolysis of phosphodiester bonds. They play a crucial role in regulating intracellular signaling by controlling the levels of cyclic nucleotides (cAMP and cGMP). There are at least 11 different mammalian PDE families, each with varying substrate specificities, tissue distributions, and regulatory properties. PDEs are important therapeutic targets, with inhibitors used to treat various diseases, including cardiovascular disorders and erectile dysfunction.
- Other names
- Phosphodiesterase
02
Mechanism of action
Inhibition of phosphodiesterase activity, leading to increased levels of cAMP or cGMP.
03
Biological functions
Signal transductionRegulation of intracellular signalingHydrolysis of phosphodiestersRegulation of cAMP levelsRegulation of cGMP levels
04
Disease associations
Cardiovascular diseaseCancerErectile dysfunctionOther pathologies
05
Safety considerations
Potential for drug interactions due to widespread expression and isoform diversity.Off-target effects due to structural similarity between PDE families.
06
Interacting drugs
Sildenafil
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