Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
The phosphorus cycle is a biogeochemical process that involves the movement of phosphorus through the lithosphere, hydrosphere, and biosphere[1][5]. Unlike other nutrient cycles, the phosphorus cycle is relatively slow and does not include a significant atmospheric component[2][5]. Phosphorus exists in several major pools in ecosystems, including dissolved inorganic phosphorus (DIP), dissolved organic phosphorus (DOP), particulate inorganic phosphorus (PIP), and particulate organic phosphorus (POP)[1]. The cycle begins with weathering of phosphorus-containing rocks, releasing phosphate salts into soil and water bodies[5]. Plants absorb these phosphates, which are then transferred to animals through consumption[5]. When organisms die, decomposition returns phosphorus to the environment, where it can be recycled or eventually form new sedimentary rocks[5]. Biologically, phosphorus is essential for numerous critical functions. It forms the backbone of DNA and RNA molecules, making it fundamental for genetic information storage and transmission[1][3][8]. Phosphorus is a key component of ATP (adenosine triphosphate), which serves as the primary energy currency in cells[3][7]. It also constitutes an important part of cell membranes as phospholipids, contributes to bone and teeth structure as hydroxyapatite (approximately 80% of phosphorus in humans is found in teeth and bones), and participates in acid-base homeostasis[1][5][7]. In plants, phosphorus homeostasis is regulated through complex signaling pathways, including the phosphate starvation response (PSR) pathway, mitogen-activated protein kinase (MAPK) pathway, calcium-dependent protein kinase (CDPK) pathway, and target of rapamycin (TOR) pathway[6]. These mechanisms help plants adapt to varying phosphorus availability in the environment. In aquatic ecosystems, phosphorus often acts as a limiting nutrient for productivity, and excessive phosphorus input can lead to eutrophication[3][4]. The availability of phosphorus is a key factor controlling photosynthesis in these environments[3]. Human activities, particularly mining for fertilizer production and agricultural practices, have significantly altered the natural phosphorus cycle, creating both environmental challenges and concerns about the sustainability of phosphorus resources[4].
Not applicable
Beyond the preview
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Explore the programs pursuing this target and their development progress.
Follow the clinical studies evaluating therapies directed at this target.
Compare approaches across drug candidates, modalities, and indications.
Investigate the research and source evidence behind target biology and development.
Explore patent activity around therapies and technologies addressing this target.
Connect target biology, drug development, and emerging evidence in your research.
See how Gosset can support your research on Phosphorus Cycle (P Cycle).