Phosphorylase b kinase regulatory subunit beta (PHKB)

Phosphorylase b kinase regulatory subunit beta (PHKB) is one of four major subunits (alpha, beta, gamma, delta) forming the phosphorylase b kinase holoenzyme, responsible for activating glycogen phosphorylase by phosphorylation. The beta subunit primarily regulates the enzyme's activity via phosphorylation and is present in both muscle and liver isoforms. Deficiency or mutation of the PHKB gene impairs glycogen breakdown, leading to glycogen accumulation, glucose shortage, and associated clinical syndromes, most notably glycogen storage disease type IXb.

Other names

phosphorylase kinase beta subunitphosphorylase kinase beta-subunitphosphorylase kinase subunit betaphosphorylase kinase, betaKPBB_HUMANPhosphorylase kinase regulatory subunit betaPHKB