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Phosphorylated Annexin A2 (p-ANXA2)
- Target
- p-ANXA2
- Molecular classification
- Annexin, Phospholipid-binding protein
01
Overview
Phosphorylated annexin A2 (p-ANXA2) is a post-translationally modified form of annexin A2, a calcium-dependent phospholipid-binding protein. Phosphorylation, typically on tyrosine or serine residues, regulates its structure and function in cellular processes like membrane trafficking, aggregation, and exocytosis. It interacts with partners like S100A10/S100A4 and F-actin. Altered expression or phosphorylation is linked to cancer progression and fibrinolytic disorders.
- Other names
- Phosphorylated Annexin IIPhosphorylated Lipocortin IIp-Annexin A2p-ANXA2
02
Mechanism of action
Modulation of membrane binding and protein-protein interactions via phosphorylation-dependent conformational changes.
03
Biological functions
Membrane traffickingMembrane aggregationEndocytosisExocytosisCytoskeletal linkagePlasminogen activationFibrinolysis
04
Disease associations
CancerCancer invasionCancer metastasisFibrinolytic disorders
05
Safety considerations
Potential for off-target effects due to pleiotropic functionsDysregulation of fibrinolysis
06
Biomarkers
ANXA2 expression levelANXA2 phosphorylation status
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