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Phosphorylated Histone H2AX (γH2AX)

Target: γH2AX
Molecular classification: Histone modification, DNA damage response protein

Overview

Phosphorylated histone H2AX, commonly referred to as γH2AX, is a variant of the histone H2A family. It is specifically phosphorylated at serine 139 in response to DNA double-strand breaks (DSBs), serving as a sensitive marker for DNA damage and repair processes. It plays a critical role in initiating DNA repair processes, making it a significant target for understanding genomic stability and disease mechanisms.

Other names: gamma H2AXH2AX phosphorylated at serine 139

Mechanism of action

N/A

Biological functions

DNA repairChromatin remodelingCell cycle checkpointRecruitment of DNA repair proteinsGenome stability

Disease associations

CancerNeurological disordersGenomic instability

Biomarkers

DNA damageResponse to cancer therapy

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