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Target intelligence / Profile preview
Phosphorylated p68 RNA Helicase (p-p68)
- Target
- p-p68
- Molecular classification
- Enzyme, RNA Helicase, DEAD-box Helicase, Post-translationally Modified Protein
01
Overview
Phosphorylated p68 refers to the post-translationally modified form of the p68 RNA helicase (DDX5), a DEAD-box family member. Phosphorylation, particularly at residues like Tyr593, modulates p68's activity, RNA binding, and interactions, impacting RNA metabolism, gene expression, and cancer progression. It is a potential therapeutic target in diseases with aberrant phosphorylation.
- Other names
- Phosphorylated DDX5Phospho-p68p68 RNA Helicase (phosphorylated)
02
Mechanism of action
Inhibition of helicase activity, disruption of protein-protein interactions, modulation of phosphorylation status.
03
Biological functions
RNA metabolismPre-mRNA splicingTranscriptional regulationRibosomal biogenesisATP-dependent RNA unwinding
04
Disease associations
CancerCell growth dysregulationGene expression dysregulation
05
Safety considerations
Potential off-target effects on other RNA helicasesUnintended consequences on RNA metabolism and gene expression
06
Biomarkers
p-Tyr593 p68 expression levelsTotal p68 expression levels
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