Target intelligence / Profile preview

Photosynthetic capacity enhancement (PCE)

Target
PCE
Molecular classification
Biological process, Plant physiological trait, Other
01

Overview

Photosynthetic capacity enhancement is a physiological and biotechnological objective focused on increasing the rate and efficiency of carbon dioxide fixation and solar energy conversion in plants (Wikipedia, 2024). It is not a single molecular target but rather a coordinated trait achieved by optimizing the activity of multiple enzymes and pathways, such as Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) and Sedoheptulose-1,7-bisphosphatase (SBPase) (Long et al., 2015; Raines, 2011). The primary biological functions involve improving the Calvin-Benson cycle, optimizing electron transport through complexes like Cytochrome b6f, and reducing energy losses from photorespiration (PMC, 2022). While this concept is not a therapeutic target for human disease, it is critical in the field of agricultural biotechnology for addressing global food security, malnutrition, and climate change through enhanced crop yields and carbon sequestration (ScienceDaily, 2020). There are no clinical drugs targeting this process in humans; however, research-level agricultural applications utilize genetic modifications and plant growth regulators to achieve these efficiency gains (Simkin et al., 2019). Monitoring the effectiveness of such enhancements typically involves physiological metrics such as the maximum quantum yield of photosystem II and net carbon assimilation rates (Frontiers in Plant Science, 2022).

Other names
Increased photosynthetic efficiencyPhotosynthetic optimizationCarbon assimilation enhancementEngineering crop photosynthesisPhotosynthetic performance enhancement
02

Mechanism of action

Upregulation of Calvin cycle enzymes, optimization of photosynthetic electron transport, reduction of photorespiratory loss, and engineering of carbon-concentrating mechanisms

03

Biological functions

Carbon fixationCalvin-Benson cycle regulationPhotosynthetic electron transportLight energy conversionPhotorespiration mitigationBiomass accumulation
04

Disease associations

Other (Food insecurity)Other (Malnutrition)Other (Climate change mitigation)
05

Safety considerations

Sink-source imbalanceIncreased nitrogen and nutrient demandEcological competition and weedinessGenetic stability of transgenic traitsPotential for altered water-use efficiency
06

Biomarkers

Chlorophyll fluorescence (Fv/Fm)Net CO2 assimilation rate (Pn)Maximum carboxylation rate (Vcmax)Stomatal conductance (gs)Biomass yield

Beyond the preview

Go deeper on Photosynthetic capacity enhancement (PCE).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Full profile access

Explore the programs pursuing this target and their development progress.

  • Drug candidates
  • Developers
  • Development stage

Clinical trials

Full profile access

Follow the clinical studies evaluating therapies directed at this target.

  • Trial design
  • Status
  • Readouts

Competitive landscape

Full profile access

Compare approaches across drug candidates, modalities, and indications.

  • Programs
  • Modalities
  • Indications

Literature & evidence

Full profile access

Investigate the research and source evidence behind target biology and development.

  • Publications
  • Sources
  • Analysis

Patents

Full profile access

Explore patent activity around therapies and technologies addressing this target.

  • Patents
  • Assignees
  • Technologies

Research & analysis

Full profile access

Connect target biology, drug development, and emerging evidence in your research.

  • Biology
  • Development news
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Photosynthetic capacity enhancement (PCE).

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call