Physical barrier at surgical site

Physical barriers at surgical sites are medical materials—often films, hydrogels, or fiber meshes—applied to wound surfaces during surgery to physically separate adjacent tissues and reduce the risk of post-surgical adhesions. These devices are made from biocompatible and often biodegradable polymers such as oxidized regenerated cellulose, hyaluronic acid, carboxymethylcellulose, poly(lactic acid), or synthetic materials like expanded polytetrafluoroethylene. Their function does not involve selective molecular recognition; instead, they act by preventing tissues from adhering as they heal. Examples include products like Seprafilm (hyaluronic acid/carboxymethylcellulose), Interceed (oxidized regenerated cellulose), and Preclude (expanded PTFE). While generally considered safe, effectiveness varies and challenges such as incomplete coverage, need for removal, or inflammatory reactions are clinical concerns[1][2][3][4].

Other names

Adhesion barriersurgical barrieranti-adhesion barrierphysical barrier devicepost-surgical adhesion barrier

Physical tissue separation; some may include delivery of anti-inflammatory agents or drugs to enhance anti-adhesion effect[1][2][4]