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Target intelligence / Profile preview
Physical Barrier on Skin
- Molecular classification
- Extracellular matrix, Lipid membrane, Structural protein complex
01
Overview
The physical barrier on the skin, primarily the stratum corneum, is a complex structure composed of corneocytes and a lipid matrix that protects the body from external threats, regulates water loss, and maintains homeostasis. It is not a specific target but is a functional barrier that is essential for skin health.
- Other names
- Stratum corneumSkin barrierEpidermal barrierCutaneous barrier
02
Mechanism of action
Enhancement/restoration of lipid matrix; reduction of inflammation; antimicrobial action
03
Biological functions
Protection from pathogensPrevention of water lossUV radiation protectionMaintenance of skin pHInnate immunity
04
Disease associations
EczemaPsoriasisContact dermatitisIchthyosisInfectionsAllergic reactions
05
Safety considerations
Compromised barrier can increase drug absorption and potential for systemic side effectsOveruse of topical corticosteroids can thin the skin and impair barrier functionIrritation or allergic reactions to topical productsPotential for infection in compromised skin
06
Interacting drugs
Emollients
4 more in the full profile.
07
Biomarkers
Transepidermal water loss (TEWL)Skin hydration levelsInflammatory markers (e.g., cytokines)Lipid composition of stratum corneum
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