Physiologic plasma protein network (PPPN)

The physiologic plasma protein network refers to the complex, interconnected assembly of thousands of proteins circulating in the blood plasma that maintain systemic homeostasis. This network encompasses diverse functional groups, including transport proteins like albumin, the coagulation cascade, the complement system, and various signaling cytokines and hormones. Rather than being a single therapeutic target, it represents a systems-biology concept used to understand how the proteome reflects the physiological state of an organism. In disease states, the network's equilibrium is disrupted, making it a rich source for biomarker discovery and multi-target therapeutic strategies. Because it is a broad biological system rather than a specific receptor or enzyme, it is generally considered too broad to be classified as a discrete drug target.

Other names

Plasma proteomeBlood protein networkCirculating protein interactome

Not applicable as this is a systems-level network rather than a single molecular target.