Physiological ligands and solutes

Physiological ligands and solutes is a broad pharmacological classification rather than a specific molecular target, encompassing endogenous substances such as neurotransmitters, hormones, metabolites, and inorganic ions (Source: IUPHAR/BPS Guide to Pharmacology). These molecules are essential for maintaining biological homeostasis, facilitating cellular signaling, and regulating metabolic processes across all organ systems (Source: PubChem). For example, ions like sodium and potassium are critical for membrane potential, while hormones like insulin regulate glucose metabolism. In a therapeutic context, these substances may be administered directly as replacement therapies—such as levothyroxine for hypothyroidism or electrolyte solutions for dehydration—or their pathways may be targeted by synthetic drugs to modulate physiological responses (Source: StatPearls). Because this term refers to a heterogeneous group of chemical entities rather than a single protein or gene product, it is typically used as a high-level organizational heading in drug discovery databases to categorize the natural partners of receptors and transporters. Consequently, it does not represent a discrete site of drug action but rather a functional grouping of the body's natural biochemical toolkit.

Other names

Endogenous ligandsPhysiological solutesEndogenous biochemicalsNatural ligands

Replacement therapy or modulation of endogenous signaling pathways to restore physiological balance.