Physiological plasma protein interaction network

The physiological plasma protein interaction network represents the comprehensive set of physical and functional interactions among proteins found in human blood plasma (Anderson & Anderson, 2002, Molecular & Cellular Proteomics). This network is vital for systemic physiology, encompassing processes such as the complement cascade, blood clotting, and the transport of lipids and hormones (Schenk et al., 2008, BMC Medical Genomics). It is characterized by a wide dynamic range of protein concentrations, from high-abundance proteins like serum albumin to low-abundance cytokines and growth factors. While the network as a whole is a system-level concept rather than a discrete therapeutic target, many of its constituent proteins are primary targets for pharmacological intervention (Nanjappa et al., 2014, Journal of Proteomics). Analyzing this network helps in understanding disease mechanisms and identifying multi-protein biomarkers for clinical diagnostics (Schwenk et al., 2017, Nature Communications). Because it describes a collection of interacting molecules rather than a single receptor or enzyme, it is classified as a biological system rather than a specific drug target.

Other names

Human plasma protein-protein interaction networkPlasma interactomeBlood protein networkPlasma proteome

Not applicable as this represents a biological system or network rather than a single molecular target.