Physiological plasma proteins and coagulation system

The physiological plasma proteins and coagulation system represent a complex network of proteins circulating in the blood that maintain vascular integrity, osmotic balance, and immune defense. This system includes the coagulation cascade—a series of zymogens and enzymes such as Factor X and Thrombin that lead to fibrin clot formation—as well as non-enzymatic proteins like albumin and immunoglobulins (StatPearls, 2023). Dysregulation of this system is central to numerous pathologies, including thromboembolic disorders like deep vein thrombosis and stroke, as well as bleeding disorders such as hemophilia (NIH, 2022). Pharmacological intervention typically involves anticoagulants that inhibit specific proteases, antiplatelet agents, or replacement therapies using purified or recombinant plasma proteins (PubMed, 2021). Monitoring these targets is critical in clinical settings, often requiring standardized assays like the International Normalized Ratio (INR) to balance efficacy and the risk of hemorrhage (IUPHAR/BPS, 2023).

Other names

Blood coagulation systemHemostatic systemPlasma proteomeCoagulation cascade

Inhibition of serine proteases in the coagulation cascade, antagonism of vitamin K epoxide reductase, or replacement of deficient plasma proteins and clotting factors.