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Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)
- Target
- PHYHIPL
- Molecular classification
- Other (Uncharacterized protein, not classified as enzyme, transporter, receptor, etc.), Fibronectin type III domain containing (family association)
01
Overview
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL) is a human protein encoded by the PHYHIPL gene on chromosome 10. It is primarily located in the cytoplasm and may play a role in the development of the central nervous system and cell metabolism, although its specific molecular function remains uncharacterized. Gene expression is detected in multiple tissues, with elevated levels in the kidney and involvement in certain disease states such as gastric small cell carcinoma and potentially as a protective gene in glioblastoma. No drugs or targeted therapies are known to interact with PHYHIPL, and its relevance as a direct therapeutic target is unsubstantiated at present.
- Other names
- PHYHIPLKIAA1796UNQ6309/PRO20934Em:AC025038.1Phytanoyl-CoA 2-hydroxylase interacting protein like
02
Biological functions
Possible role in development of the central nervous systemPossible functions in cell metabolismMay influence cellular stress response and protein ubiquitination (by similarity to similar uncharacterized proteins and predicted domains)
03
Disease associations
Possibly associated with gastric small cell carcinoma (through gene-disease associations, but not as a therapeutic target)Implicated as a protective gene in glioblastoma multiforme (GBM; expression is reduced in grade IV GBM, but functional evidence is lacking)Potential upregulation after viral infection, suggesting roles in infection response (orthologous mouse/cat data for C11orf96, presumed to be equivalent)
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