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Target intelligence / Profile preview
Piercer of microtubule wall 2 protein (PIERCE2)
- Target
- PIERCE2
- Molecular classification
- Other (microtubule inner protein)
01
Overview
Piercer of microtubule wall 2 protein (PIERCE2) is a protein coding gene involved in the structure and function of ciliary axonemes, specifically acting as a microtubule inner protein that supports the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules in the axoneme, which is required for proper motile cilia beating[1]. It is localized within the axonemal microtubule and predicted to contribute to processes such as axoneme assembly, establishment of left-right symmetry during development, and the motility of flagellated sperm[1]. PIERCE2 lacks catalytic activity, acts as a structural or scaffolding component, and does not currently have known pharmaceutical ligands or roles as a canonical therapeutic target[3]. No direct disease associations or functional links to pathogenesis are established based on current human data.
- Other names
- C15orf65FLJ27352C14orf65piercer of microtubule wall 2 proteinuncharacterized protein C15orf65PIRC2PIERCE2
02
Biological functions
Axoneme assemblyDetermination of left/right symmetryFlagellated sperm motilityAttachment of outer dynein arms to cilia axoneme
03
Disease associations
Other (no direct disease linkage identified in currently available data)
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