Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
PiggyBac transposable element-derived protein 4 (PGBD4)
- Target
- PGBD4
- Molecular classification
- Other (transposon-derived protein; not a receptor, enzyme, ion channel, transporter, transcription factor, or histone modification)
01
Overview
PiggyBac transposable element-derived protein 4 (PGBD4) is part of the piggyBac transposase family, which originates from a transposon found in diverse animal genomes including humans. It is a human protein of approximately 67 kDa, and while its ancestral transposase function is evident from sequence homology, the PGBD4 protein itself does not act as a canonical transposase, nor does it show obvious transpositional or enzymatic activity in humans. Its molecular and cellular functions remain largely uncharacterized, with no clear biological pathways or disease mechanisms established as of current knowledge. Some data link variation in PGBD4 to neurodevelopmental disorders with eye movement abnormalities, but its mechanistic role, if any, in disease is undetermined. There is no evidence for its use as a therapeutic target, nor is there structured clinical knowledge about its safety, biomarkers, or small molecule interactions.
- Other names
- FLJ32638FLJ37497PGBD4piggyBac transposable element derived 4piggyBac transposable element-derived protein 4
02
Mechanism of action
no known drugs, thus no known mechanism
03
Biological functions
Other (unknown; the protein’s physiological function in humans is uncharacterized)
04
Disease associations
Other (tentatively linked to neurodevelopmental disorder with eye movement abnormalities; no established disease mechanism)
Beyond the preview
Go deeper on PiggyBac transposable element-derived protein 4 (PGBD4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PiggyBac transposable element-derived protein 4 (PGBD4).