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Target intelligence / Profile preview
Pigment Epithelium-Derived Factor (PEDF)
- Target
- PEDF
- Molecular classification
- Serine protease inhibitor (serpin) superfamily, Glycoprotein, Secreted protein
01
Overview
Pigment Epithelium-Derived Factor (PEDF), also known as Serpin F1, is a multifunctional, secreted glycoprotein belonging to the non-inhibitory serpin family. It is a potent endogenous inhibitor of angiogenesis and exhibits neurotrophic and antitumor properties. PEDF is widely expressed across various tissues and organs and plays a role in retinal and neurodegenerative diseases, cancer, fibrosis, and metabolic syndrome. Its expression is regulated by sex steroids/hormones and TGF-beta signaling.
- Other names
- Serpin F1SERPINF1
02
Mechanism of action
PEDF exerts its effects through multiple mechanisms, including promoting neuronal differentiation and survival, inhibiting angiogenesis by inducing endothelial cell apoptosis and suppressing proliferation, and modulating inflammation and fibrosis. The precise signaling pathways involved depend on the specific microenvironment and post-translational modifications.
03
Biological functions
Neurotrophic activityAnti-angiogenic activityAnti-tumor activityAnti-metastatic activityRegulation of inflammationModulation of fibrosisRegulation of metabolism
04
Disease associations
Retinal degenerative diseasesCancerIdiopathic pulmonary fibrosisMetabolic syndromeInsulin resistanceType II diabetes
05
Safety considerations
Dosage optimizationDurability of therapeutic effectsContext-dependent effects (e.g., potential promotion of stem cell growth in glioma)Efficacy in large animal models
06
Biomarkers
Hepatocellular carcinoma
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