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Pigment Epithelium-Derived Factor-Derived Short Peptide (PEDF-derived short peptide)
- Target
- PEDF-derived short peptide
- Molecular classification
- Peptide
01
Overview
Pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein with potent neuroprotective and antiangiogenic properties. Short peptides derived from PEDF have been developed to harness specific biological activities of the full-length protein, such as neuroprotection and inhibition of angiogenesis. These peptides offer advantages like improved stability, reduced antigenicity, and lower production cost compared to full-length PEDF.
- Other names
- PEDF peptideAsp44–Asn77 (34-mer)Asn60–Asn77 (18-mer)Val78–Thr121 (44-mer)Ser93–Gln98 (6-mer)P14P18P2329-mer
02
Mechanism of action
Inhibition of VEGF signaling, induction of apoptosis via p53/Bax/caspase pathway, activation of neuronal survival receptors.
03
Biological functions
Anti-angiogenesisNeuroprotectionNeurotrophic activityApoptosis modulation
04
Disease associations
Retinal diseasesDiabetic retinopathyAge-related macular degenerationIschemia-reperfusion injuryCancerProstate cancerRenal cell carcinomaDry eye disease
05
Safety considerations
Potential for off-target effects if not sequence-specific.Need to optimize delivery methods for specific applications (e.g., ocular administration).
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