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Target intelligence / Profile preview
PIK3CA E545K Mutant (PIK3CA E545K)
- Target
- PIK3CA E545K
- Molecular classification
- Enzyme, Kinase, PI3K, Mutant Protein
01
Overview
The PIK3CA E545K mutation is an oncogenic point mutation in the PIK3CA gene, resulting in constitutive activation of PI3K signaling, promoting uncontrolled cell growth and survival. It is found in various cancers and can influence response to PI3K inhibitors.
- Other names
- PIK3CA exon 10 mutationp110α E545KPIK3CA c.1634A>G
02
Mechanism of action
Inhibition of PI3K signaling
03
Biological functions
Cell proliferationCell survivalCell migrationMetabolismPI3K/AKT/mTOR signaling
04
Disease associations
CancerBreast cancerColon cancerGlioblastomaCervical squamous cell carcinomaBladder cancerHead & neck squamous cell carcinomaDrug resistance
05
Safety considerations
Potential for off-target effects of PI3K inhibitorsDevelopment of resistance to PI3K inhibitors
06
Interacting drugs
Alpelisib
3 more in the full profile.
07
Biomarkers
PIK3CA E545K mutation status for patient selectionPIK3CA E545K mutation status for predicting response to PI3K inhibitors
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