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PIK3CA H1047X
- Target
- PIK3CA H1047X
- Molecular classification
- Enzyme, Kinase, PI3K subunit, Phosphatidylinositol 3-kinase
01
Overview
PIK3CA H1047X refers to any missense mutation in the PIK3CA gene at amino acid position 1047 that results in increased PI3K enzymatic activity. This gain-of-function mutation is a common oncogenic driver, particularly in breast, colorectal, and bladder cancers, leading to enhanced cell proliferation, survival, and migration. The presence of H1047X mutations may impact treatment response and is being explored as a biomarker for targeted therapies.
- Other names
- PIK3CA H1047RPIK3CA H1047LPIK3CA Histidine 1047 MutationPIK3CA exon 20 mutation
02
Mechanism of action
PI3K inhibition
03
Biological functions
Cell growthCell proliferationCell survivalCell migrationProtein synthesisMetabolismSignal transduction
04
Disease associations
CancerBreast CancerColorectal CancerBladder Cancer
05
Safety considerations
Potential resistance to therapiesIncreased angiogenesisTreatment-related adverse events
06
Interacting drugs
RLY-2608
5 more in the full profile.
07
Biomarkers
PIK3CA H1047X mutation status
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