PIK3R5 divergent transcript (PIK3R5-DT)

PIK3R5-DT is a divergent transcript (non-coding RNA) located adjacent to the PIK3R5 gene, which encodes phosphoinositide-3-kinase regulatory subunit 5, a protein involved in class IB PI3K signaling—important in cell growth, proliferation, differentiation, motility, and survival[1][3][9]. PIK3R5-DT itself is not characterized as a protein-coding gene and lacks experimental evidence for direct biological function or clinical relevance. Most available data and disease associations pertain to the protein-coding PIK3R5 gene, not the divergent transcript. Synonyms such as CTB-41I6.1 and CTB-41I6.2 denote alternate transcript names with limited functional annotation[5]. If you seek information on therapeutic targets, the functionally relevant entity is the Phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), not the divergent transcript. PIK3R5 (protein) is implicated in oncogenesis and other pathophysiological processes, but PIK3R5-DT does not currently have sufficient evidence to be considered a molecular target for therapy or drug development[1][3][9]. The distinction between PIK3R5-DT (RNA, non-coding transcript) and PIK3R5 (protein-coding) is critical. PIK3R5-DT has not been established as a biological target, and information is limited to transcript annotation databases[5]. This term should be used with caution if your aim is to reference therapeutic targets.

Other names

CTB-41I6.1CTB-41I6.2PIK3R5-DT