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PIM Family Kinases (PIM Kinases)

Target: PIM Kinases
Molecular classification: Enzyme, Serine/threonine kinase

Overview

The PIM family kinases are a group of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. They play significant roles in cell survival, proliferation, apoptosis, and oncogenesis. These constitutively active enzymes are involved in cell cycle progression, metabolism, and migration. They are overexpressed in many cancers, especially hematologic malignancies and solid tumors. Due to their role in cancer cell survival/proliferation, PIM kinases are considered promising targets for anticancer drug development.

Other names: PIM1PIM2PIM3

Mechanism of action

Inhibition of PIM kinase activity, blocking pro-survival pathways and reversing drug resistance.

Biological functions

Cell survivalCell proliferationApoptosis regulationCell cycle progressionMetabolismCell migrationRegulation of gene expressionMYC target gene activationChromatin remodeling

Disease associations

CancerHematologic malignanciesAcute myeloid leukemiaSolid tumorsProstate cancerHepatocellular carcinoma

Safety considerations

Potential for redundancy or compensation among family membersLimited impact when knocked out individually suggests need for combination therapiesSafety window for therapeutic inhibition targeting these kinases specifically within cancer contexts rather than normal tissue homeostasis

Interacting drugs

PIM inhibitors

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