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Target intelligence / Profile preview
Pim Kinase Family (Pim)
- Target
- Pim
- Molecular classification
- Serine/threonine kinase, Enzyme, CAMK group (calmodulin-dependent protein kinase-related)
01
Overview
Pim kinases are a family of constitutively active serine/threonine kinases (Pim-1, Pim-2, and Pim-3) that regulate cell proliferation, survival, apoptosis, and migration. They are implicated in various cancers, especially hematologic malignancies and prostate cancer, making them attractive targets for anti-cancer drug development. Pim kinases act as cofactors for oncogenic transcription factors such as c-MYC.
- Other names
- Pim-1Pim-2Pim-3Proto-oncogene serine/threonine-protein kinase Pim-1
02
Mechanism of action
Inhibition of Pim kinase activity
03
Biological functions
Cell cycle regulationApoptosis inhibitionCell survivalTranscriptional regulationSignal transductionCell proliferationCell migration
04
Disease associations
CancerHematological malignancies (AML, lymphomas)Prostate cancerSolid tumors
05
Interacting drugs
Pim kinase inhibitors
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