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Target intelligence / Profile preview
Pituitary adenylate cyclase-activating polypeptide receptor (PAC1R)
- Target
- PAC1R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a class B GPCR and the primary high-affinity receptor for PACAP. It plays important roles in neuronal function and various physiological processes. Dysregulation has been implicated in disorders such as PTSD, migraine, and metabolic syndromes. Therapeutics targeting either the peptide or receptor are under investigation.
- Other names
- PAC1ADCYAP1R1
02
Mechanism of action
Ligand binding activates Gαs and Gαq pathways, leading to increased cAMP/PKA and IP3/DAG/Ca²⁺/PKC signaling respectively.
03
Biological functions
NeurotransmissionNeuroprotectionHormone secretionEnergy homeostasisMetabolic homeostasisSignal transduction
04
Disease associations
PTSDMigraineMetabolic syndromes
05
Safety considerations
Elevated cAMP in trigeminal neurons may sensitize neurons
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