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Target intelligence / Profile preview
Piwi-like protein 1 (PIWIL1)
- Target
- PIWIL1
- Molecular classification
- Argonaute protein, RNA-binding protein, Endoribonuclease
01
Overview
PIWIL1 is a member of the PIWI subfamily of Argonaute proteins involved in RNA silencing, translational regulation, and stem cell self-renewal. It plays a central role in germline function by repressing transposable elements and is essential for spermatogenesis. In cancer, PIWIL1 acts as an oncogenic factor, promoting tumor cell proliferation, EMT, invasion, cancer stem-like properties, and chemoresistance through both piRNA-dependent and piRNA-independent mechanisms. Its overexpression correlates with poor prognosis in multiple tumors, making it a potential biomarker and therapeutic target.
- Other names
- HIWIMIWICT80.1PIWIpiwi like RNA-mediated gene silencing 1
02
Mechanism of action
Inhibition of PIWIL1 activity to suppress tumor cell proliferation, EMT, invasion, cancer stem-like properties, tumorigenesis, metastasis, and chemoresistance.
03
Biological functions
RNA silencingTranslational regulationStem cell self-renewalRepression of transposable elementsSpermatogenesispiRNA pathway
04
Disease associations
CancerTumor initiation and progression
05
Safety considerations
Potential for off-target effects due to its role in essential cellular processesTherapeutic challenges related to specific and effective targeting of PIWIL1 without disrupting normal germline function
06
Biomarkers
PIWIL1 expression levels as a diagnostic and prognostic marker in various cancers
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