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Placebo refers to a substance or treatment that has no therapeutic effect, such as an inert pill (e.g., sugar pill), saline injection, or sham medical procedure, and is commonly used in clinical trials as a control to measure the efficacy of active treatments. Placebos work through psychological mechanisms, such as expectation and belief, and their use helps isolate the true pharmacological or physiological effects of an intervention from non-specific effects or patient/observer bias[1][4][7][10].
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