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Target intelligence / Profile preview
Placenta-expressed transcript 1 protein (PLET1)
- Target
- PLET1
- Molecular classification
- Other (cell surface protein)
01
Overview
Placenta-expressed transcript 1 protein (PLET1) is a cell surface protein encoded by the PLET1 gene (also known as C11orf34) that is involved in processes such as cell migration, wound healing, cell-matrix adhesion, and trophoblast differentiation[3][7][1]. It exhibits a highly regulated expression pattern, being tightly repressed by DNA methylation in embryonic stem cells and expressed in trophoblast stem cells and certain differentiated cells[1][3]. PLET1 plays a critical role in balancing trophoblast self-renewal and differentiation, influencing lineage specification towards trophoblast giant cells or syncytiotrophoblast cells[1]. It is predicted to localize in the extracellular region and plasma membrane, and acts as a marker for progenitor/stem cell reservoirs[1][2][3][7]. Diseases associated with dysregulation of PLET1 include arthrogryposis multiplex congenita and DiGeorge syndrome; however, there are currently no known drugs targeting this protein[3][6].
- Other names
- C11orf34Placenta-expressed transcript 1PLET1_HUMAN
02
Biological functions
Cell migrationWound healingCell-matrix adhesionTrophoblast lineage specificationCellular differentiation
03
Disease associations
Arthrogryposis multiplex congenita 2, neurogenic typeDiGeorge syndromeCancer (by association; involved in tissue development and homeostasis)Other (organ development, tissue homeostasis, repair)
04
Biomarkers
PLET1 expression is a marker for progenitor/stem cell reservoirs and for trophoblast lineage specification
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