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Target intelligence / Profile preview
Placental Growth Factor (PlGF)
- Target
- PlGF
- Molecular classification
- Growth Factor, VEGF sub-family, Secreted Protein
01
Overview
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family, crucial for angiogenesis and vasculogenesis, especially during embryonic development and pregnancy. It is primarily produced by placental trophoblasts. PlGF regulates blood vessel formation within the placenta, supports trophoblast growth and differentiation, and facilitates remodeling of maternal spiral arteries. Low levels are associated with preeclampsia and placental dysfunction. While not essential under normal conditions, it becomes critical during pathological states like ischemia or tumorigenesis.
- Other names
- Placenta growth factorvascular endothelial growth factor-related proteinPlGF 1SHGCPGFLPIGFPLGFPlGF-2SHGC-10760
02
Mechanism of action
PlGF binds primarily to VEGFR-1 (Flt-1), influencing biological responses. sFlt-1 antagonizes PlGF activity.
03
Biological functions
AngiogenesisVasculogenesisTrophoblast growthTrophoblast differentiationRegulation of blood vessel formationSpiral artery remodeling
04
Disease associations
PreeclampsiaPlacental dysfunctionIschemiaCancer
05
Safety considerations
Therapeutic targeting of PlGF requires careful consideration due to its role in normal angiogenesis and wound healing. Complete inhibition may lead to adverse effects.Altered angiogenic response under stress conditions needs to be considered when manipulating PlGF pathways.
06
Biomarkers
Maternal serum PlGF levelssFlt-1/PlGF ratio
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