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Target intelligence / Profile preview
Placental Growth Factor 2 (PlGF-2)
- Target
- PlGF-2
- Molecular classification
- VEGF/PDGF family, Growth Factor, Secreted protein
01
Overview
Placental growth factor 2 (PlGF-2) is one of the isoforms of placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) family. PlGF-2 is a key regulator in angiogenesis and vasculogenesis, particularly during embryonic development and pregnancy. It is unique among PlGF isoforms for its strong binding to both neuropilins and heparin and its restricted temporal/spatial expression in early placenta. It modulates vascular development, pregnancy health, and pathological angiogenesis in cancer.
02
Mechanism of action
VEGFR-1 activation, Neuropilin-1/2 modulation
03
Biological functions
Angiogenesis regulationEndothelial cell growthMonocyte activationMonocyte migrationVEGFR-1 signaling support
04
Disease associations
PreeclampsiaCancer progressionCancer metastasisRetinal neovascular disorders
05
Safety considerations
Altering PlGF-2 levels can affect tumor neovascularizationPotential off-target effects on normal angiogenesis
06
Biomarkers
Low PlGF-2 levels associated with preeclampsiaHigh PlGF-2 levels associated with increased tumor migration/invasion
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