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Target intelligence / Profile preview
Placental Growth Factor Receptor 1 (VEGFR-1)
- Target
- VEGFR-1
- Molecular classification
- Receptor, Tyrosine kinase receptor
01
Overview
Placental growth factor receptor 1 (VEGFR-1 or Flt-1) is a tyrosine kinase cell-surface receptor that binds VEGF family members like PlGF, VEGFA, and VEGFB. It plays a crucial role in angiogenesis, vasculogenesis, and inflammation, particularly under pathological conditions. It's a diagnostic marker and therapeutic target for various diseases including cancer and preeclampsia.
- Other names
- Flt-1Vascular Endothelial Growth Factor Receptor 1
02
Mechanism of action
Inhibition of VEGFR-1 signaling by blocking ligand binding or receptor activation.
03
Biological functions
Angiogenesis regulationVasculogenesisArteriogenesisInflammation modulationSignal transduction
04
Disease associations
CancerInflammatory DisordersPreeclampsiaRetinopathyRheumatoid arthritisAtherosclerosisIschemia
05
Safety considerations
Potential for off-target effects on normal angiogenesisSafety and efficacy in humans still under investigation
06
Interacting drugs
Monoclonal antibodies against VEGFR-1
07
Biomarkers
sFlt-1/PlGF ratio (for preeclampsia)
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