Plakophilin 4 antisense RNA 1 (PKP4-AS1)

PKP4 antisense RNA 1 (PKP4-AS1) is a long non-coding RNA gene identified in humans, which is transcribed from the opposite strand to the PKP4 (Plakophilin 4) gene. As an antisense RNA, its principal role is presumed to involve the regulation of its sense partner gene, PKP4, likely through mechanisms such as transcriptional interference, RNA-RNA binding, or by affecting chromatin structure. There are no direct annotations for PKP4-AS1 in major gene function databases regarding its biological role, disease associations, or drug interactions[1]. PKP4 itself is involved in cellular junctions and cytoskeletal organization, but the specific impact of PKP4-AS1 remains uncharacterized. PKP4-AS1 is not considered a traditional therapeutic target such as a receptor, enzyme, or transporter and currently lacks evidence of direct association with human disease or pharmacological intervention[1].

Other names

PKP4-AS1Plakophilin 4 antisense RNA 1