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Plant cell division pathway

Molecular classification
Other
01

Overview

The **plant cell division pathway** comprises a series of highly regulated molecular and cellular events by which plant cells progress through the cell cycle and divide, ensuring growth, development, and tissue regeneration. Key features include unique mechanisms such as the formation of the phragmoplast and cell plate during cytokinesis, distinct from animal cells, which rely on a cleavage furrow[1][3][5]. Regulators of plant cell division include cyclins, cyclin-dependent kinases, microtubule-associated proteins (e.g., kinesins such as PAKRP1), and specific transcription factors like MYB3R4 that promote the expression of genes required for mitosis and cytokinesis[1][2][4]. The process is critical for meristem activity, organ formation, and tissue regeneration but is not itself a single druggable target; rather, numerous molecular targets within the pathway can be modulated experimentally or biotechnologically, for example using spindle inhibitors like colchicine[5]. **Note:** - "Plant cell division pathway" refers to a broad biological process, not a single molecule, receptor, or canonical therapeutic target. Relevant individual targets within this pathway include proteins such as cyclin-dependent kinases, MYB-related transcription factors, and microtubule motors. Therefore, this entry is classified as *is_incorrect: true* for target curation purposes.

Other names
Cell division in plantsPlant cytokinesisPlant mitosis
02

Mechanism of action

Inhibition of spindle apparatus formation (e.g., by colchicine blocking microtubule polymerization)[5]

03

Biological functions

Cell cycleCell proliferationCytokinesisSignal transduction
04

Disease associations

Other (no direct primary disease role; disruptions can affect plant growth/development, but not classified under standard human disease categories)
05

Safety considerations

Chromosomal instability in treated plantsPossible off-target effects on non-dividing cells
06

Interacting drugs

Colchicine (experimentally and in plant breeding to disrupt spindle formation)[5]

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