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Target intelligence / Profile preview
Butyrylcholinesterase (BCHE)
- Target
- BCHE
- Molecular classification
- Enzyme, Serine hydrolase, Cholinesterase
01
Overview
Butyrylcholinesterase (BChE), also known as pseudocholinesterase, is a nonspecific cholinesterase enzyme that hydrolyzes a wide range of choline-based esters. Primarily synthesized in the liver and found in blood plasma, it plays a crucial role in drug metabolism and detoxification. Genetic deficiencies can lead to prolonged effects of certain anesthetics. BChE is also implicated in various diseases, including Alzheimer's disease and cocaine addiction, making it a potential therapeutic target.
- Other names
- PseudocholinesterasePlasma cholinesteraseSerum cholinesteraseCHE1CHE2E1BCHED
02
Mechanism of action
Hydrolyzes ester bonds, leading to inactivation/breakdown of substrate drugs and toxins. Recombinant forms or gene therapy approaches are also used to sequester substrates such as cocaine.
03
Biological functions
Drug metabolismDetoxificationHydrolysis of ester-containing compounds
04
Disease associations
Alzheimer's diseaseInsulin resistanceType 2 diabetes mellitusCognition disordersHepatic diseasesCardiovascular/cerebrovascular diseasesInflammationObesityParkinson’s diseaseCocaine addiction
05
Safety considerations
Prolonged apnea after administration of certain anesthetic drugs in individuals with BChE deficiencyPotential for drug interactions due to broad substrate specificity
06
Interacting drugs
Succinylcholine
3 more in the full profile.
07
Biomarkers
BChE activity levels (for predicting anesthetic sensitivity)Amyloid-beta levels (in Alzheimer's disease)
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