Plasma filtration with selective adsorbent columns

Selective plasma filtration with adsorbent columns refers to a class of extracorporeal blood purification procedures in which plasma is separated from whole blood and passed through columns containing selective adsorbent materials. These columns use physical and chemical properties (such as pore size, affinity ligands, or hydrophobic/ionic interactions) to specifically remove unwanted substances—such as autoantibodies, cytokines, or endotoxins—while returning the bulk of desirable plasma proteins to the patient[1][2][3][4]. Techniques include "coupled plasma filtration and adsorption" (CPFA) and immunoadsorption. These therapies are primarily used as adjuncts in the treatment of systemic inflammatory conditions (such as sepsis or fulminant hepatic failure), with the aim of lowering circulating levels of inflammatory mediators, immune complexes, or toxins. This approach does not target a specific molecule or receptor, but operates by physical removal mechanisms. Selective adsorbent columns may employ materials such as cellulose diacetate membranes or affinity beads[1][2].

Other names

Selective plasma filtrationSelective plasma exchangePlasma adsorption therapyCoupled plasma filtration adsorption

Blood or plasma is separated and passed through selective adsorbent columns to remove targeted pathogenic substances by filtration or adsorption[1][2][3][4]