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Plasma Kallikrein Precursor (PKK)
- Target
- PKK
- Molecular classification
- Serine Protease, Enzyme, Zymogen
01
Overview
Plasma kallikrein precursor, also known as prekallikrein, is a glycoprotein encoded by the KLKB1 gene. It is synthesized in the liver and circulates in the blood. Upon activation, primarily by factor XIIa, it is converted into plasma kallikrein, an active serine protease involved in blood coagulation, fibrinolysis, kinin generation, and inflammation.
- Other names
- PrekallikreinFletcher FactorKLKB1
02
Mechanism of action
Inhibition of kallikrein activation; blockade of kallikrein activity to reduce bradykinin production
03
Biological functions
Blood coagulationFibrinolysisKinin generationInflammationVasodilation
04
Disease associations
InflammationAngioedemaCancerThrombosis
05
Safety considerations
Potential for bleeding complications with excessive inhibitionRisk of thromboembolic events with complete kallikrein blockade
06
Biomarkers
KLKB1 expression levels in cancerPrekallikrein levels in coagulation disorders
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