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Target intelligence / Profile preview
Plasma Lipoprotein Lipase Activity (LPL)
- Target
- LPL
- Molecular classification
- Enzyme, Hydrolase, Glycoprotein
01
Overview
Plasma lipoprotein lipase (LPL) activity refers to the enzymatic function of LPL, a key extracellular enzyme anchored to the vascular endothelium, primarily in adipose tissue, skeletal muscle, and heart tissue. Its main role is to hydrolyze triglycerides carried by circulating lipoproteins—specifically chylomicrons and very low-density lipoproteins (VLDL)—into free fatty acids and glycerol.
- Other names
- Lipoprotein lipaseLPL Activity
02
Mechanism of action
Hydrolyzes triglycerides carried by circulating lipoproteins into free fatty acids and glycerol.
03
Biological functions
Triglyceride HydrolysisLipid Uptake FacilitationRegulation of Plasma Lipids
04
Disease associations
HypertriglyceridemiaFamilial ChylomicronemiaCardiovascular Disease
05
Safety considerations
Dysregulation can lead to atherosclerosis or pancreatitis.
06
Interacting drugs
Heparin
4 more in the full profile.
07
Biomarkers
Plasma LPL activity
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