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Plasma membrane Ca2+ channel (Leishmania)
- Molecular classification
- Ion channel, Calcium channel
01
Overview
The plasma membrane Ca2+ channel in Leishmania species is a key component in the parasite's calcium homeostasis. It is functionally similar to L-type voltage-gated Ca2+ channels (VGCCs) but exhibits distinct pharmacological properties, including activation by sphingosine and miltefosine. It is considered a main target for miltefosine, and possibly other antileishmanial agents. Its unique activation profile makes it a promising target for selective therapeutic intervention against Leishmania parasites.
- Other names
- Leishmania plasma membrane calcium channelLeishmania voltage-gated-like calcium channel
02
Mechanism of action
Activation of the channel by miltefosine leads to calcium influx, disruption of intracellular calcium homeostasis, and alkalinization of acidocalcisomes, contributing to parasite death.
03
Biological functions
Calcium ion transportRegulation of cytosolic calcium levelsCell signaling
04
Disease associations
Leishmaniasis
05
Safety considerations
Potential for off-target effects on host calcium channels, although Leishmania channel exhibits unique pharmacology.
06
Interacting drugs
Miltefosine
2 more in the full profile.
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