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Target intelligence / Profile preview
Magnesium-dependent Calcium Transport ATPase (PMCA)
- Target
- PMCA
- Molecular classification
- Enzyme, P-type ion transporting ATPases, Transporter
01
Overview
The magnesium-dependent calcium transport ATPase (PMCA) is a P-type ATPase enzyme crucial for cellular calcium homeostasis. It actively transports Ca²⁺ ions out of the cytosol across the plasma membrane using ATP hydrolysis, dependent on both Mg²⁺ and Ca²⁺. PMCA maintains low intracellular free calcium, essential for signaling. Dysfunction is linked to neurodegenerative and cardiac diseases.
- Other names
- Plasma Membrane Calcium ATPaseAtp2b isoforms
02
Mechanism of action
Inhibition of ATP hydrolysis and Ca²⁺ transport
03
Biological functions
Calcium homeostasisActive transportATP hydrolysisSignal transduction
04
Disease associations
Neurodegenerative diseaseCardiac contractility disorders
05
Safety considerations
Dysregulation can impair calcium clearance from cellsPotential for off-target effects with inhibitors
06
Interacting drugs
Aurintricarboxylic acid (ATA)
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