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Plasmepsin IX (PMIX)

Target: PMIX
Molecular classification: Enzyme, Aspartic protease

Overview

Plasmepsin IX (PMIX) is an aspartic protease enzyme found in *Plasmodium falciparum*. It is essential for the proteolytic maturation of rhoptry proteins, which are required for merozoite invasion of host erythrocytes, making it a validated target for antimalarial drug development. Inhibitors targeting PMIX block parasite development by preventing successful erythrocyte invasion.

Mechanism of action

Inhibition of aspartic protease activity, preventing rhoptry protein maturation and blocking erythrocyte invasion

Biological functions

ProteolysisRhoptry protein processingErythrocyte invasion

Disease associations

Malaria

Interacting drugs

WM382

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