Target intelligence / Profile preview

Plasmepsin X (PMX)

Target: PMX
Molecular classification: Aspartyl protease, Enzyme

Overview

Plasmepsin X (PMX) is an essential aspartyl protease found in the malaria parasite *Plasmodium falciparum*. It plays a critical role in multiple stages of the parasite's life cycle, including egress from and invasion into erythrocytes, development of functional liver merozoites, and blocking transmission to mosquitoes. These functions make PMX a highly attractive multistage drug target for antimalarial therapy.

Mechanism of action

Inhibition of Plasmepsin X activity, leading to disruption of multiple stages of the *Plasmodium falciparum* life cycle.

Biological functions

Erythrocyte egressErythrocyte invasionSUB1 activationLiver-stage developmentTransmission processes

Disease associations

InfectionMalaria

Interacting drugs

UCB7362

2 more in the full profile.

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