Plasminogen activator, urokinase receptor mRNA (PLAUR mRNA) (PLAUR mRNA)

Plasminogen activator, urokinase receptor (PLAUR) mRNA is the transcript that encodes the uPAR protein (also known as CD87), a key regulator of the plasminogen activation system (UniProt P14317). uPAR is a GPI-anchored receptor that binds urokinase-type plasminogen activator (uPA), facilitating the conversion of plasminogen to plasmin, which leads to extracellular matrix degradation and promotes cell migration and tissue remodeling (PubMed: 25151354). In various cancers, PLAUR mRNA is frequently overexpressed, correlating with increased tumor invasiveness, metastasis, and poor patient prognosis (PubMed: 17068487). Therapeutic strategies targeting PLAUR mRNA include the use of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) to silence uPAR expression at the pre-translational level. These RNA-based approaches aim to inhibit the proteolytic and signaling functions of uPAR, thereby reducing tumor growth and spread in preclinical models (PubMed: 15623601). Additionally, PLAUR mRNA levels and the resulting soluble uPAR (suPAR) protein serve as significant biomarkers for disease severity and inflammatory status (PubMed: 21934643).

Other names

uPAR mRNACD87 mRNAU-PAR mRNAPlasminogen activator, urokinase receptor transcript

Antisense inhibition and RNA interference (siRNA) leading to the degradation of PLAUR mRNA and subsequent reduction in uPAR protein expression (PubMed: 15623601).