Target intelligence / Profile preview

Plasminogen Activator Enzyme (PA)

Target: PA
Molecular classification: Enzyme, Serine Protease

Overview

Plasminogen activators are serine protease enzymes that convert plasminogen to plasmin, initiating fibrinolysis and regulating blood clot dissolution. Key types include tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). These enzymes play crucial roles in hemostasis, tissue remodeling, cell migration, and synaptic plasticity. Recombinant tPA is used therapeutically for thrombolysis, but excessive or insufficient activity can lead to bleeding complications or increased thrombosis risk, respectively.

Other names: tPAuPATissue-type Plasminogen ActivatorUrokinase-type Plasminogen Activator

Mechanism of action

Catalyzes the conversion of plasminogen to plasmin, which degrades fibrin in blood clots.

Biological functions

FibrinolysisTissue RemodelingCell MigrationSynaptic PlasticityExtracellular Matrix Degradation

Disease associations

ThrombosisEmbolismIschemic StrokeMyocardial InfarctionPulmonary EmbolismInflammationTumor Invasion

Safety considerations

Hyperfibrinolysis (bleeding complications)Hypofibrinolysis (increased risk of thrombosis or embolism)

Interacting drugs

rtPA (recombinant tissue-type plasminogen activator)

Beyond the preview

Go deeper on Plasminogen Activator Enzyme (PA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Plasminogen Activator Enzyme (PA).

Explore the full profile