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Target intelligence / Profile preview
Plasminogen Activator Inhibitor-1-Binding Protein
- Molecular classification
- Protein-protein interaction, Extracellular matrix protein binding
01
Overview
Plasminogen activator inhibitor-1-binding protein refers to proteins that interact with plasminogen activator inhibitor-1 (PAI-1), a key serine protease inhibitor (serpin) in the regulation of fibrinolysis and extracellular matrix remodeling. The most well-characterized PAI-1 binding partner is vitronectin, but PAI-1 also interacts with other molecules such as the urokinase-type plasminogen activator receptor (uPAR), low-density lipoprotein receptor-related protein 1 (LRP1), and various matrix proteins. Binding partners modulate PAI-1’s stability, activity, localization, and its broader roles in cell adhesion, migration, proliferation, apoptosis regulation, wound healing, angiogenesis, inflammation, tissue fibrosis, cardiovascular disease progression, cancer biology—including tumor growth—and cellular senescence.
02
Mechanism of action
Modulation of PAI-1 stability, activity, localization, and signaling functions
03
Biological functions
Regulation of fibrinolysisExtracellular matrix remodelingCell adhesionCell migrationCell proliferationApoptosis regulationWound healingAngiogenesisInflammationTissue fibrosisCellular senescence
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Disease associations
ThrombosisFibrosisCancerMetabolic syndromeObesityHemorrhagic diathesisCardiovascular disease
05
Safety considerations
Altered levels or function can lead to thrombosis or hemorrhagic diathesisElevated levels can correlate with poor prognosis in cancer
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