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Target intelligence / Profile preview
Plasminogen Activator Inhibitor Type 1 (PAI-1)
- Target
- PAI-1
- Molecular classification
- Serine protease inhibitor, Serpin
01
Overview
Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (serpin) and the principal physiological inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which are enzymes responsible for converting plasminogen to plasmin, thereby promoting fibrinolysis. It plays roles in clot regulation, extracellular matrix degradation, wound healing, angiogenesis, cell migration, and is implicated in diseases such as thrombosis, fibrosis, and cancer.
- Other names
- Serpin E1SERPINE1
02
Mechanism of action
Inhibition of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA)
03
Biological functions
Inhibition of tPAInhibition of uPARegulation of fibrinolysisModulation of extracellular matrix degradationWound healingAngiogenesisCell migrationCell invasion
04
Disease associations
ThrombosisHemorrhagic diathesisObesityMetabolic syndromeCardiovascular diseaseCancerFibrosisAging-related diseases
05
Safety considerations
Inhibition can lead to bleedingOver-inhibition can lead to thrombosis
06
Biomarkers
Plasma PAI-1 levels
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