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Target intelligence / Profile preview
Plasminogen activator urokinase (uPA)
- Target
- uPA
- Molecular classification
- Serine protease, Enzyme
01
Overview
Plasminogen activator urokinase (uPA) is a serine protease enzyme that converts inactive plasminogen into active plasmin, crucial for fibrinolysis, tissue remodeling, and pathological processes like cancer invasion and metastasis. It interacts with its receptor, uPAR, to localize proteolytic activity and initiate intracellular signaling.
- Other names
- UrokinaseuPAUrokinase-type Plasminogen Activator
02
Mechanism of action
Catalyzes the conversion of plasminogen to plasmin, leading to fibrin degradation and ECM remodeling. Binding to uPAR initiates intracellular signaling pathways.
03
Biological functions
FibrinolysisECM degradationWound healingPlasminogen activationCell motilityCell proliferationCell survivalCell adhesionCell migration
04
Disease associations
CancerInflammationCardiovascular diseaseThrombosis
05
Safety considerations
Bleeding risk (for thrombolytic use)Potential for off-target effects on tissue remodelingImmunogenicity (for antibody-based therapies)Resistance to inhibitors
06
Interacting drugs
Urokinase (as thrombolytic agent)
2 more in the full profile.
07
Biomarkers
uPA levels (prognostic in cancer)uPAR levels (prognostic in cancer)suPAR (soluble uPAR, associated with inflammation and cardiovascular disease)
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