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Target intelligence / Profile preview
Plasminogen activator urokinase-type receptor (uPAR)
- Target
- uPAR
- Molecular classification
- Receptor, Glycoprotein
01
Overview
Plasminogen activator urokinase-type receptor (uPAR), also known as the urokinase receptor or CD87, is a multidomain cell surface glycoprotein. It plays a key role in pericellular plasmin formation, cell adhesion, migration, invasion, proliferation, survival and angiogenesis. uPAR is implicated in tissue remodeling during physiological processes and pathological conditions such as cancer invasion/metastasis and vascular damage, making it an attractive therapeutic target.
- Other names
- Urokinase receptorCD87Urokinase plasminogen activator surface receptor
02
Mechanism of action
Inhibition of uPAR to prevent tumor progression or metastasis formation.
03
Biological functions
Cell adhesionMigrationInvasionProliferationSurvivalAngiogenesisRegulation of pericellular plasmin formation
04
Disease associations
CancerInflammationWound HealingVascular Damage
05
Safety considerations
Potential for off-target effects due to uPAR involvement in normal tissue remodeling
06
Biomarkers
uPAR expression levels in tumors
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